Conta as aventuras de Sabrina Spellman que, aos 16 anos, descobre que é uma bruxa. Suas tias Hilda e Zelda lhes dão conselhos sobre como usar seus poderes mágicos de maneira apropriada, mas, apesar de seu esforço, Sabrina sempre se mete em grandes trapalhadas por ainda não dominar os feitiços.
On her sixteenth birthday, Sabrina Spellman finds out that she is a witch. However, instead of helping her, it actually makes life more difficult, especially after she gets on the wrong side of head cheerleader, Libby.
Sabrina slips Libby some truth sprinkles to make her confess to spreading nasty lies, but her plan backfires when the goodies make Jenny reveal she's sweet on Sabrina's love interest, Harvey. Meanwhile, Hilda prepares for a date with Drell - despite his having stood her up over 1,000 times in the past.
In an attempt at earning some money to buy roller blades, Sabrina takes a job babysitting a little boy. However, when she is trying to calm him down, she inadvertently casts a spell which turns him into a man.
When Sabrina is left feeling down because Harvey has agreed to go to the school dance with Libby, her aunts literally cook up a date for her, but nonetheless she still pines for him.
Em uma tentativa de chamar a atenção de Harvey, Sabrina arranja um trabalho como assistente de um mágico, mas as coisas saem do controle quando ela faz o mágico desaparecer acidentalmente.
Depressed by her lack of talent at sports, Sabrina casts a spell which makes her brilliant at Kung Fu, but when she beats a seasoned professional, her conscience bothers her.
After spending the weekend at Jenny's, under the advice of her aunts, Sabrina reluctantly invites Jenny to her house. However, when Jenny enters the linen closet, she ends up in the Other Realm, at the mercy of Drell.
Sabrina and her aunts take a trip to Mars, but Sabrina is reluctant to leave Harvey. She agrees to call him at a specified time, but when her attractive ski instructor takes a shine to her, she soon forgets about the mortal world.
As Sabrina and Harvey grow closer, her aunts reveal that when a witch kisses a mortal for the first time, the mortal turns into a frog. Unable to stop herself, however, Sabrina kisses Harvey, and must find a way to change him back.
Sinister plots, tumultuous romance, danger, and intrigue - just another day at Westbridge High, after Sabrina casts a spell wishing for more excitement.